Thesis

Abstract Kidney stones are common in all kinds of urolithiasis The study focuses on Polyherbal extracts containing Boerhavia diffusa Celosia argentea and Plumeria rubra seed pod was prepared and evaluated for Antilithiatic by in vivo method The traditional system of medicine includes the use of many herbal medicines for the treatment of kidney stone due to the presence of Flavonoids triterpenoids glycosides and other chemicals having different mode of action This study was conducted on Ethylene glycol induced rats to examine the antilithiatic potential of selected herbs The effect three medicinal plants ie Boerhavia diffusa celosia argentea and Plumeria rubra studied by in vivo method for their litholytic activity The polyherbal extract of 400mg per Kg was shown better effect it was found from urine analysis that in disease control animals calcium phosphorus and oxalate excretion were significantly increased while the magnesium level decreased when compared with Normal group animals Also from serum analysis it was found that the treatment of rats with Extract 1 200 and extract 2 ie 400 mg per kg and Cystone 750 mg per kg exhibited significant increment in Serum Calcium Serum Phosphorus Serum BUN Serum Creatinine and increment in Serum Uric acid when compared with DC rats Thus poyherbal extract of 400mg per Kg of all the three plants was found to be effective for the treatment of Kidney stone