Thesis

Colchicine is one of the drug which is preferably used in the treatment of rheumatoid arthritis.It has been surveyed that only oral dosage form is available in the form of tablet. In last several decades, trial has been made in order to overcome the problem drug molecule to get available in blood stream, maximally. of In this current research work the attempt was made to develop a drug delivery which will help to make the drug molecule available at the site of application, as stratum corneum plays role of barrier and resist the entry of drug molecule to get enter into the blood stream. Transdermal drug delivery gains benefit of bypassing gastrointestinal aggravations and hepatic metabolizing effects which are unit related to the oral route. In this study, base was prepared by using carbopol 940, TEA, PEG, IPA, methyl paraben and propyl paraben as preservatives and required amount of water in quantity sufficient to produce 100g. The formulationswere prepared and evaluated for their pH, Spreadability, irritati